5vax
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Bcl-2 complex with Beclin 1 BH3 domain== | |
| - | + | <StructureSection load='5vax' size='340' side='right' caption='[[5vax]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vax]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VAX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vau|5vau]], [[5vay|5vay]], [[5vb1|5vb1]], [[5vb4|5vb4]]</td></tr> |
| - | [[Category: Fairlie, W | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [http://pdbe.org/5vax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [http://www.ebi.ac.uk/pdbsum/5vax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fairlie, W D]] | ||
| + | [[Category: Lee, E F]] | ||
| + | [[Category: Smith, B J]] | ||
[[Category: Yao, S]] | [[Category: Yao, S]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Autophagy]] |
| + | [[Category: Bcl-2]] | ||
| + | [[Category: Beclin 1]] | ||
Revision as of 05:53, 4 April 2018
Bcl-2 complex with Beclin 1 BH3 domain
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Categories: Fairlie, W D | Lee, E F | Smith, B J | Yao, S | Apoptosis | Autophagy | Bcl-2 | Beclin 1
