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5xrr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crystal structure of FUS (54-59) SYSSYG== |
| - | + | <StructureSection load='5xrr' size='340' side='right' caption='[[5xrr]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xrr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XRR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xrr OCA], [http://pdbe.org/5xrr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xrr RCSB], [http://www.ebi.ac.uk/pdbsum/5xrr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xrr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gui, X]] | ||
| + | [[Category: Li, D]] | ||
| + | [[Category: Liu, C]] | ||
| + | [[Category: Zhao, M]] | ||
| + | [[Category: Hydrous amyloid fibril spine]] | ||
| + | [[Category: Low complexity domain]] | ||
| + | [[Category: Reversible amyloid]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Rna granule assembly]] | ||
Revision as of 05:55, 4 April 2018
Crystal structure of FUS (54-59) SYSSYG
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