6b3t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b== | |
| - | + | <StructureSection load='6b3t' size='340' side='right' caption='[[6b3t]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b3t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJ7:8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole'>CJ7</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3t OCA], [http://pdbe.org/6b3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3t RCSB], [http://www.ebi.ac.uk/pdbsum/6b3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EIS_MYCTU EIS_MYCTU]] May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.<ref>PMID:10629183</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gajadeera, C S]] | ||
[[Category: Garneau-Tsodikova, S]] | [[Category: Garneau-Tsodikova, S]] | ||
| - | [[Category: Ngo, H.X]] | ||
| - | [[Category: Tsodikov, O.V]] | ||
| - | [[Category: Gajadeera, C.S]] | ||
[[Category: Hou, C]] | [[Category: Hou, C]] | ||
| + | [[Category: Ngo, H X]] | ||
| + | [[Category: Tsodikov, O V]] | ||
| + | [[Category: Aminoglycoside]] | ||
| + | [[Category: Resistance]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
| + | [[Category: Tuberculosis]] | ||
Revision as of 05:57, 4 April 2018
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b
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