6b92

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m (Protected "6b92" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6b92 is ON HOLD until Paper Publication
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==Crystal Structure of the N-terminal domain of human METTL16 in complex with SAH==
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<StructureSection load='6b92' size='340' side='right' caption='[[6b92]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Ruszkowska, A., Ruszkowski, M., Dauter, Z., Brown, J.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6b92]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B92 FirstGlance]. <br>
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Description: Crystal Structure of the N-terminal domain of human METTL16 in complex with SAH
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b91|6b91]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b92 OCA], [http://pdbe.org/6b92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b92 RCSB], [http://www.ebi.ac.uk/pdbsum/6b92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b92 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MET16_HUMAN MET16_HUMAN]] RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753). In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200). Also able to bind various lncRNAs (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311).<ref>PMID:27872311</ref> <ref>PMID:28525753</ref> <ref>PMID:29051200</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brown, J A]]
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[[Category: Dauter, Z]]
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[[Category: Ruszkowska, A]]
[[Category: Ruszkowski, M]]
[[Category: Ruszkowski, M]]
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[[Category: Ruszkowska, A]]
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[[Category: Methyltransferase-like protein 16]]
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[[Category: Dauter, Z]]
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[[Category: N6-methyladenosine]]
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[[Category: Brown, J.A]]
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[[Category: Rna methylation]]
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[[Category: S-adenosylhomocysteine]]
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[[Category: S-adenosylmethionine]]
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[[Category: Transferase]]

Revision as of 05:57, 4 April 2018

Crystal Structure of the N-terminal domain of human METTL16 in complex with SAH

6b92, resolution 2.10Å

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