6cc8

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m (Protected "6cc8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6cc8 is ON HOLD until Apr 04 2019
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==Crystal structure MBD3 MBD domain in complex with methylated CpG DNA==
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<StructureSection load='6cc8' size='340' side='right' caption='[[6cc8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6cc8]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CC8 FirstGlance]. <br>
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Description: Crystal structure MBD3 MBD domain in complex with methylated CpG DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cc8 OCA], [http://pdbe.org/6cc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cc8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cc8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN]] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
[[Category: Liu, K]]
[[Category: Liu, K]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Edwards, A.M]]
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[[Category: Structural genomic]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Sgc]]

Revision as of 05:59, 4 April 2018

Crystal structure MBD3 MBD domain in complex with methylated CpG DNA

6cc8, resolution 1.95Å

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OCA

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