2ggp
From Proteopedia
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|PDB= 2ggp |SIZE=350|CAPTION= <scene name='initialview01'>2ggp</scene> | |PDB= 2ggp |SIZE=350|CAPTION= <scene name='initialview01'>2ggp</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CU1:COPPER (I) ION'>CU1</scene> | + | |LIGAND= <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] </span> |
|GENE= ATX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CCC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= ATX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CCC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggp OCA], [http://www.ebi.ac.uk/pdbsum/2ggp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ggp RCSB]</span> | ||
}} | }} | ||
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[[Category: SPINE, Structural Proteomics in Europe.]] | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
[[Category: Voulgaris, P.]] | [[Category: Voulgaris, P.]] | ||
| - | [[Category: CU1]] | ||
[[Category: complex]] | [[Category: complex]] | ||
[[Category: copper transport]] | [[Category: copper transport]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:16:26 2008'' |
Revision as of 00:16, 31 March 2008
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| Ligands: | |||||||
| Gene: | ATX1 (Saccharomyces cerevisiae), CCC2 (Saccharomyces cerevisiae) | ||||||
| Activity: | Copper-exporting ATPase, with EC number 3.6.3.4 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the Atx1-Cu(I)-Ccc2a complex
Overview
Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners.
About this Structure
2GGP is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction., Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato A, Voulgaris P, Nat Chem Biol. 2006 Jul;2(7):367-8. Epub 2006 May 28. PMID:16732294
Page seeded by OCA on Mon Mar 31 03:16:26 2008
Categories: Copper-exporting ATPase | Protein complex | Saccharomyces cerevisiae | Banci, L. | Bertini, I. | Cantini, F. | Felli, I C. | Gonnelli, L. | Hadjiliadis, N. | Pierattelli, R. | Rosato, A. | SPINE, Structural Proteomics in Europe. | Voulgaris, P. | Complex | Copper transport | Nmr | Spine | Structural genomic | Structural proteomics in europe
