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5wb5
From Proteopedia
(Difference between revisions)
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<StructureSection load='5wb5' size='340' side='right' caption='[[5wb5]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='5wb5' size='340' side='right' caption='[[5wb5]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wb5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WB5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WB5 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF4E1, LMJF_27_1620 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA]), LMJF_35_3980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wb5 OCA], [http://pdbe.org/5wb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wb5 RCSB], [http://www.ebi.ac.uk/pdbsum/5wb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wb5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wb5 OCA], [http://pdbe.org/5wb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wb5 RCSB], [http://www.ebi.ac.uk/pdbsum/5wb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wb5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Leishmania parasites are unicellular pathogens that are transmitted to humans through the bite of infected sandflies. Most of the regulation of their gene expression occurs post-transcriptionally, and the different patterns of gene expression required throughout the parasites' life cycle are regulated at the level of translation. Here, we report the X-ray crystal structure of the Leishmania cap-binding isoform 1, LeishIF4E-1, bound to a protein fragment of previously unknown function, Leish4E-IP1, that binds tightly to LeishIF4E-1. The molecular structure, coupled to NMR spectroscopy experiments and in vitro cap-binding assays, reveal that Leish4E-IP1 allosterically destabilizes the binding of LeishIF4E-1 to the 5' mRNA cap. We propose mechanisms through which Leish4E-IP1-mediated LeishIF4E-1 inhibition could regulate translation initiation in the human parasite. | ||
| + | |||
| + | Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.,Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Leger-Abraham M Nucleic Acids Res. 2018 Mar 19. pii: 4942471. doi: 10.1093/nar/gky194. PMID:29562352<ref>PMID:29562352</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5wb5" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Leima]] | ||
[[Category: Arthanari, H]] | [[Category: Arthanari, H]] | ||
[[Category: Boeszoermenyi, A]] | [[Category: Boeszoermenyi, A]] | ||
Revision as of 06:51, 4 April 2018
Leishmania IF4E-1 bound to Leishmania 4E-IP1
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Categories: Leima | Arthanari, H | Boeszoermenyi, A | Leger-Abraham, M | Meleppattu, S | Shapira, M | Wagner, G | Zinoviev, A | Cap | Initiation factor | Leishmania | Parasite | Translation
