5wmm
From Proteopedia
(Difference between revisions)
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<StructureSection load='5wmm' size='340' side='right' caption='[[5wmm]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='5wmm' size='340' side='right' caption='[[5wmm]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wmm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wmm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Micromonospora_sp._ml1 Micromonospora sp. ml1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMM FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6G:(2S)-2-amino-3-methylbutanoyl+(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl+hydrogen+(S)-phosphate'>B6G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6G:(2S)-2-amino-3-methylbutanoyl+(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl+hydrogen+(S)-phosphate'>B6G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tioS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349725 Micromonospora sp. ML1]), tioT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349725 Micromonospora sp. ML1])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmm OCA], [http://pdbe.org/5wmm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmm RCSB], [http://www.ebi.ac.uk/pdbsum/5wmm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmm OCA], [http://pdbe.org/5wmm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmm RCSB], [http://www.ebi.ac.uk/pdbsum/5wmm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interrupted adenylation domains are enigmatic fusions, in which one enzyme is inserted into another to form a highly unusual bifunctional enzyme. We present the first crystal structure of an interrupted adenylation domain that reveals a unique embedded methyltransferase. The structure and functional data provide insight into how these enzymes N-methylate amino acid precursors en route to nonribosomal peptides. | ||
| + | |||
| + | Structural basis for backbone N-methylation by an interrupted adenylation domain.,Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S Nat Chem Biol. 2018 Mar 19. pii: 10.1038/s41589-018-0014-7. doi:, 10.1038/s41589-018-0014-7. PMID:29556104<ref>PMID:29556104</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5wmm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Micromonospora sp. ml1]] | ||
[[Category: Garneau-Tsodikova, S]] | [[Category: Garneau-Tsodikova, S]] | ||
[[Category: Mori, S]] | [[Category: Mori, S]] | ||
Revision as of 06:51, 4 April 2018
Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS
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