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2gku
From Proteopedia
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|PDB= 2gku |SIZE=350|CAPTION= <scene name='initialview01'>2gku</scene> | |PDB= 2gku |SIZE=350|CAPTION= <scene name='initialview01'>2gku</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[143d|143D]], [[186d|186D]], [[1k8p|1K8P]], [[2aqy|2AQY]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [http://www.ebi.ac.uk/pdbsum/2gku PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB]</span> | ||
}} | }} | ||
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[[Category: Patel, D J.]] | [[Category: Patel, D J.]] | ||
[[Category: Phan, A T.]] | [[Category: Phan, A T.]] | ||
| - | [[Category: | + | [[Category: 3+1 strand folding;edgewise]] |
| - | [[Category: double-chain reversal | + | [[Category: double-chain reversal loop]] |
| - | [[Category: g-tetrad | + | [[Category: g-tetrad]] |
| + | [[Category: nmr,12 structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:02 2008'' |
Revision as of 00:18, 31 March 2008
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| Ligands: | , , | ||||||
| Related: | 143D, 186D, 1K8P, 2AQY
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures
Overview
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
About this Structure
2GKU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556
Page seeded by OCA on Mon Mar 31 03:18:02 2008
