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== Disease and Relevance == | == Disease and Relevance == | ||
If we can understand<ref name="Falke">PMID: 25834953</ref> how the bacteria moves<ref name="Falke" /> we might be able to make antibiotics that can target those specific control sites and prevent diseases by halting their search for attractant molecules. | If we can understand<ref name="Falke">PMID: 25834953</ref> how the bacteria moves<ref name="Falke" /> we might be able to make antibiotics that can target those specific control sites and prevent diseases by halting their search for attractant molecules. | ||
| - | The chemoreceptors Escherichia coli and Salmonella typhimurium are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis. It proposes that strong helix packing stabilizes the receptor. | + | The chemoreceptors Escherichia coli and Salmonella typhimurium<ref name="Harris">PMID: 27295350</ref> are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis<ref name="Swain">PMID: 19705835</ref>. It proposes that strong helix packing stabilizes the receptor. |
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2)Multidimensional Solid-State Nuclear Magnetic Resonance of a Functional Multiprotein Chemoreceptor ArrayMichael J. Harris, Jochem O. Struppe, Benjamin J. Wylie, Ann E. McDermott, and Lynmarie K. Thompson* | 2)Multidimensional Solid-State Nuclear Magnetic Resonance of a Functional Multiprotein Chemoreceptor ArrayMichael J. Harris, Jochem O. Struppe, Benjamin J. Wylie, Ann E. McDermott, and Lynmarie K. Thompson* | ||
| - | 3)Engineered Socket Study of Signaling through a Four-Helix Bundle: Evidence for aYin-Yang Mechanism in the Kinase Control Module of the Aspartate | + | 3)Engineered Socket Study of Signaling through a Four-Helix Bundle: Evidence for aYin-Yang Mechanism in the Kinase Control Module of the Aspartate Receptor Kalin E. Swain, Miguel A. Gonzalez, and Joseph J. Falke |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references /> | <references /> | ||
Revision as of 23:40, 5 April 2018
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References
- ↑ 1.0 1.1 Parkinson JS, Hazelbauer GL, Falke JJ. Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub, 2015 Mar 30. PMID:25834953 doi:http://dx.doi.org/10.1016/j.tim.2015.03.003
- ↑ Harris MJ, Struppe JO, Wylie BJ, McDermott AE, Thompson LK. Multidimensional Solid-State Nuclear Magnetic Resonance of a Functional Multiprotein Chemoreceptor Array. Biochemistry. 2016 Jul 5;55(26):3616-24. doi: 10.1021/acs.biochem.6b00234. Epub, 2016 Jun 24. PMID:27295350 doi:http://dx.doi.org/10.1021/acs.biochem.6b00234
- ↑ Swain KE, Gonzalez MA, Falke JJ. Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor. Biochemistry. 2009 Oct 6;48(39):9266-77. PMID:19705835 doi:http://dx.doi.org/10.1021/bi901020d
