Histamine H1 receptor
From Proteopedia
(Difference between revisions)
(New page: ==Histamine H1 Receptor== <StructureSection load='3RZE' size='340' side='right' caption='Histamine H1 receptor with an antagonist' scene=''> Allergy symptoms are mostly caused by the relea...) |
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== Structural highlights == | == Structural highlights == | ||
| - | The structure of the H1 histamine receptor bound to an antihistamine, doxepin was published in 2011 <ref>PMID:21697825</ref>. | + | The structure of the H1 histamine receptor bound to an antihistamine, doxepin was published in 2011 <ref>PMID:21697825</ref>. A <scene name='78/784820/N_to_c_rainbow/1'>N-->C rainbow</scene> view colors the N terminus blue and the C terminus red, with the intervening segments paralleling the rainbow (blue, green, yellow, orange, red). This image is oriented with the transmembrane section at the top and the cytosolic portion below. |
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| + | <scene name='78/784820/Doxepin/2'>Doxepin</scene> binds among the transmembrane alpha helices. Binding is stabilized by a number of <scene name='78/784820/Interacting_amino_acids/1'>interactions with amino acids</scene>. Interestingly, second generation antihistamines take advantage of an anion binding site formed by <scene name='78/784820/Lys/2'>two lysine residues</scene>; in this structure, they interact with a phosphate. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 18:37, 6 April 2018
Histamine H1 Receptor
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References
- ↑ Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S. Structure of the human histamine H1 receptor complex with doxepin. Nature. 2011 Jun 22;475(7354):65-70. doi: 10.1038/nature10236. PMID:21697825 doi:10.1038/nature10236
