Vpr protein
From Proteopedia
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'''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>. | '''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>. | ||
| + | == Disease == | ||
| + | HIV-1 retrovirus is the couse of AIDS desease. HIV-1 is a RNA virus which copy its genome to the host-cell genome, in this case - the human genome, in infect cells. HIV-1 infects activated CD4 immune cells and macrophages. When the disease is expressing in carriers, the progressive depletion of CD4 T cells causes immunodeficiency. | ||
For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]]. | For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]]. | ||
Revision as of 19:04, 7 April 2018
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3D Structures of Vpr protein
Updated on 07-April-2018
1m8l – Vpr - NMR - HIV-1
1esx - synthetic Vpr - NMR - HIV-1
5jk7 – Vpr + DDB1 + DCAF-1 + UNG2 – X-ray solution - HIV-1
1x9v – Dimeric structure of the Vpr C-terminal domain - NMR
1vpc - C-terminal domain of Vpr - NMR - HIV-1
1fi0 - Vpr residues 13-33 in micelles - NMR - HIV-1
1bde - NMR solution of Vpr peptides connected to cell cycle arrest and nuclear provirus transfer
5b56 - Importin subunit alpha-1 + Vpr C-terminal domain - crystallographic analysis
1kzs, 1kzt, 1kzv - Vpr residues 34-51 - NMR - HIV-1
1dsj - Vpr residues 50-75 - NMR - HIV-1
1ceu - Vpr N-terminal domain - NMR - HIV-1
1dsk - Vpr residues 59-86 - NMR - HIV-1
4u1s - HLA-I + Beta-2-microglobulin + Vpr protein - X-ray diffraction
References
- ↑ Morellet N, Bouaziz S, Petitjean P, Roques BP. NMR structure of the HIV-1 regulatory protein VPR. J Mol Biol. 2003 Mar 14;327(1):215-27. PMID:12614620
- ↑ Gonzalez ME. The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention. Int J Mol Sci. 2017 Jan 10;18(1). pii: ijms18010126. doi: 10.3390/ijms18010126. PMID:28075409 doi:http://dx.doi.org/10.3390/ijms18010126
- ↑ Morellet N, Bouaziz S, Petitjean P, Roques BP. NMR structure of the HIV-1 regulatory protein VPR. J Mol Biol. 2003 Mar 14;327(1):215-27. PMID:12614620
