5yah
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal 2 for AtLURE1.2-AtPRK6LRR== | |
| + | <StructureSection load='5yah' size='340' side='right' caption='[[5yah]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5yah]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAH FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yah OCA], [http://pdbe.org/5yah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yah RCSB], [http://www.ebi.ac.uk/pdbsum/5yah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yah ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRK6_ARATH PRK6_ARATH]] Key receptor for sensing species-specific attractants in cooperation with other pollen receptor-like kinases. Essential for pollen tube reorientation toward attractant peptides.<ref>PMID:26961657</ref> [[http://www.uniprot.org/uniprot/LUR12_ARATH LUR12_ARATH]] Pollen tube attractants guiding pollen tubes to the ovular micropyle. Attracts specifically pollen tubes from A.thaliana, but not those from A.lyrata (PubMed:23271953). Triggers endocytosis of MDIS1 in the pollen tube tip (PubMed:26863186).<ref>PMID:23271953</ref> <ref>PMID:26863186</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Transportation of the immobile sperms directed by pollen tubes to the ovule-enclosed female gametophytes is important for plant sexual reproduction. The defensin-like (DEFL) cysteine-rich peptides (CRPs) LUREs play an essential role in pollen tube attraction to the ovule, though their receptors still remain controversial. Here we provide several lines of biochemical evidence showing that the extracellular domain of the leucine-rich repeat receptor kinase (LRR-RK) PRK6 from Arabidopsis thaliana directly interacts with AtLURE1 peptides. Structural study reveals that a C-terminal loop of the LRR domain (AtPRK6(LRR)) is responsible for recognition of AtLURE1.2, mediated by a set of residues largely conserved among PRK6 homologs from Arabidopsis lyrata and Capsella rubella, supported by in vitro mutagenesis and semi-in-vivo pollen tube growth assays. Our study provides evidence showing that PRK6 functions as a receptor of the LURE peptides in A. thaliana and reveals a unique ligand recognition mechanism of LRR-RKs. | ||
| - | + | Structural basis for receptor recognition of pollen tube attraction peptides.,Zhang X, Liu W, Nagae TT, Takeuchi H, Zhang H, Han Z, Higashiyama T, Chai J Nat Commun. 2017 Nov 6;8(1):1331. doi: 10.1038/s41467-017-01323-8. PMID:29109411<ref>PMID:29109411</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5yah" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chai, J]] | ||
| + | [[Category: Zhang, X]] | ||
| + | [[Category: Cysteine-rich peptide]] | ||
| + | [[Category: Leucine-rich repeat receptor kinase]] | ||
| + | [[Category: Plant protein]] | ||
| + | [[Category: Pollen tube guidance]] | ||
| + | [[Category: Receptor-ligand complex]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 13:47, 11 April 2018
Crystal 2 for AtLURE1.2-AtPRK6LRR
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