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2gum
From Proteopedia
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|PDB= 2gum |SIZE=350|CAPTION= <scene name='initialview01'>2gum</scene>, resolution 2.10Å | |PDB= 2gum |SIZE=350|CAPTION= <scene name='initialview01'>2gum</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | + | |LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
| - | |GENE= GB, UL27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= GB, UL27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gum OCA], [http://www.ebi.ac.uk/pdbsum/2gum PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gum RCSB]</span> | ||
}} | }} | ||
| Line 16: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2GUM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 2GUM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUM OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of glycoprotein B from herpes simplex virus 1., Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC, Science. 2006 Jul 14;313(5784):217-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16840698 16840698] | Crystal structure of glycoprotein B from herpes simplex virus 1., Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC, Science. 2006 Jul 14;313(5784):217-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16840698 16840698] | ||
| - | [[Category: Human herpesvirus | + | [[Category: Human herpesvirus 1]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Heldwein, E E.]] | [[Category: Heldwein, E E.]] | ||
| - | [[Category: NA]] | ||
[[Category: envelope glycoprotein]] | [[Category: envelope glycoprotein]] | ||
[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
[[Category: virus]] | [[Category: virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:50 2008'' |
Revision as of 00:21, 31 March 2008
| |||||||
| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | GB, UL27 (Human herpesvirus 1) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I
Overview
Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
About this Structure
2GUM is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.
Reference
Crystal structure of glycoprotein B from herpes simplex virus 1., Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC, Science. 2006 Jul 14;313(5784):217-20. PMID:16840698
Page seeded by OCA on Mon Mar 31 03:21:50 2008
