2gux
From Proteopedia
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|PDB= 2gux |SIZE=350|CAPTION= <scene name='initialview01'>2gux</scene>, resolution 2.00Å | |PDB= 2gux |SIZE=350|CAPTION= <scene name='initialview01'>2gux</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2gty|2GTY]], [[2guc|2GUC]], [[2gud|2GUD]], [[2gue|2GUE]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gux OCA], [http://www.ebi.ac.uk/pdbsum/2gux PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gux RCSB]</span> | ||
}} | }} | ||
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[[Category: Wlodawer, A.]] | [[Category: Wlodawer, A.]] | ||
[[Category: Ziolkowska, N E.]] | [[Category: Ziolkowska, N E.]] | ||
| - | [[Category: SO4]] | ||
[[Category: domain swapping]] | [[Category: domain swapping]] | ||
[[Category: griffithsin]] | [[Category: griffithsin]] | ||
| Line 32: | Line 34: | ||
[[Category: sar]] | [[Category: sar]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:55 2008'' |
Revision as of 00:21, 31 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Related: | 2GTY, 2GUC, 2GUD, 2GUE
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Selenomethionine derivative of griffithsin
Overview
The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a beta prism consisting of three four-stranded sheets, with an approximate 3-fold axis, of another molecule. The structure of each monomer bears close resemblance to jacalin-related lectins, but its dimeric structure is unique. The structures of complexes of griffithsin with mannose and N-acetylglucosamine defined the locations of three almost identical carbohydrate binding sites on each monomer. We have also shown that griffithsin is a potent inhibitor of the coronavirus responsible for severe acute respiratory syndrome (SARS). Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes.
About this Structure
2GUX is a Single protein structure of sequence from Griffithsia. Full crystallographic information is available from OCA.
Reference
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding., Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A, Structure. 2006 Jul;14(7):1127-35. PMID:16843894
Page seeded by OCA on Mon Mar 31 03:21:55 2008
Categories: Griffithsia | Single protein | Wlodawer, A. | Ziolkowska, N E. | Domain swapping | Griffithsin | Hiv | Lectin | Mannose binding | Sar
