2gv2
From Proteopedia
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|PDB= 2gv2 |SIZE=350|CAPTION= <scene name='initialview01'>2gv2</scene>, resolution 1.80Å | |PDB= 2gv2 |SIZE=350|CAPTION= <scene name='initialview01'>2gv2</scene>, resolution 1.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=1AC:1-AMINOCYCLOPROPANECARBOXYLIC+ACID'>1AC</scene>, <scene name='pdbligand=6CW:6-CHLORO-L-TRYPTOPHAN'>6CW</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=PM3:2-AMINO-3-(4-PHOSPHONOMETHYL-PHENYL)-PROPIONIC+ACID'>PM3</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ycr|1YCR]], [[1t4f|1T4F]], [[1t4e|1T4E]], [[1rv1|1RV1]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gv2 OCA], [http://www.ebi.ac.uk/pdbsum/2gv2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gv2 RCSB]</span> | ||
}} | }} | ||
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[[Category: Sakurai, K.]] | [[Category: Sakurai, K.]] | ||
[[Category: Schubert, C.]] | [[Category: Schubert, C.]] | ||
| - | [[Category: ACE]] | ||
[[Category: optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]] | [[Category: optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:58 2008'' |
Revision as of 00:22, 31 March 2008
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| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | MDM2 (Homo sapiens) | ||||||
| Related: | 1YCR, 1T4F, 1T4E, 1RV1
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
MDM2 in complex with an 8-mer p53 peptide analogue
Overview
The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.
About this Structure
2GV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2., Sakurai K, Schubert C, Kahne D, J Am Chem Soc. 2006 Aug 30;128(34):11000-1. PMID:16925398
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