2gx9
From Proteopedia
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|PDB= 2gx9 |SIZE=350|CAPTION= <scene name='initialview01'>2gx9</scene>, resolution 2.100Å | |PDB= 2gx9 |SIZE=350|CAPTION= <scene name='initialview01'>2gx9</scene>, resolution 2.100Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SCN:THIOCYANATE ION'>SCN</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Segment 8 - NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11309 unidentified influenza virus]) | |GENE= Segment 8 - NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11309 unidentified influenza virus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gx9 OCA], [http://www.ebi.ac.uk/pdbsum/2gx9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gx9 RCSB]</span> | ||
}} | }} | ||
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[[Category: Bornholdt, Z A.]] | [[Category: Bornholdt, Z A.]] | ||
[[Category: Prasad, B V.]] | [[Category: Prasad, B V.]] | ||
| - | [[Category: SCN]] | ||
[[Category: alpha-helix beta-crescent]] | [[Category: alpha-helix beta-crescent]] | ||
[[Category: effector domain]] | [[Category: effector domain]] | ||
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[[Category: ns1]] | [[Category: ns1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:49 2008'' |
Revision as of 00:22, 31 March 2008
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| , resolution 2.100Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | Segment 8 - NS1 (unidentified influenza virus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray strucutre of influenza virus NS1 effector domain
Overview
The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.
About this Structure
2GX9 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.
Reference
X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094
Page seeded by OCA on Mon Mar 31 03:22:49 2008
