2h03

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|PDB= 2h03 |SIZE=350|CAPTION= <scene name='initialview01'>2h03</scene>, resolution 1.650&Aring;
|PDB= 2h03 |SIZE=350|CAPTION= <scene name='initialview01'>2h03</scene>, resolution 1.650&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=3UN:(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID'>3UN</scene>
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|LIGAND= <scene name='pdbligand=3UN:(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC+ACID'>3UN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
|GENE= PTPRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= PTPRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=[[2ho2|2HO2]], [[2ho4|2HO4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h03 OCA], [http://www.ebi.ac.uk/pdbsum/2h03 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h03 RCSB]</span>
}}
}}
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[[Category: Pokross, M E.]]
[[Category: Pokross, M E.]]
[[Category: Walter, R L.]]
[[Category: Walter, R L.]]
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[[Category: 3UN]]
 
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[[Category: CL]]
 
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[[Category: MG]]
 
[[Category: drug design]]
[[Category: drug design]]
[[Category: inhibitor]]
[[Category: inhibitor]]
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[[Category: wpd-loop]]
[[Category: wpd-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:10:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:23:37 2008''

Revision as of 00:23, 31 March 2008

Image:2h03.gif


PDB ID 2h03

Drag the structure with the mouse to rotate
, resolution 1.650Å
Ligands: , ,
Gene: PTPRB (Homo sapiens)
Activity: Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Related: 2HO2, 2HO4


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors


Overview

The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.

About this Structure

2H03 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta., Amarasinghe KK, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. Epub 2006 Jun 12. PMID:16759857

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