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5tos

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'''Unreleased structure'''
 
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The entry 5tos is ON HOLD until Paper Publication
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==Botrytis-induced kinase 1 (BIK1) from Arabidopsis thaliana==
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<StructureSection load='5tos' size='340' side='right' caption='[[5tos]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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Authors: Hurlburt, N.K., Lal, N.K., Fisher, A.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5tos]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TOS FirstGlance]. <br>
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Description: Botrytis-induced kinase 1 (BIK1) from Arabidopsis thaliana
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Fisher, A.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tos OCA], [http://pdbe.org/5tos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tos RCSB], [http://www.ebi.ac.uk/pdbsum/5tos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tos ProSAT]</span></td></tr>
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[[Category: Hurlburt, N.K]]
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</table>
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[[Category: Lal, N.K]]
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== Function ==
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[[http://www.uniprot.org/uniprot/BIK1_ARATH BIK1_ARATH]] Plays a central role in immune responses (PubMed:20413097). Required to activate the resistance responses to necrotrophic pathogens (PubMed:16339855). Phosphorylates FLS2 and BAK1 (PubMed:20404519, PubMed:24104392). Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2. Acts additively with PBL1 in PTI defenses (PubMed:20413097). Acts as positive regulator of the PAMP flg22-induced increase of cytosolic calcium. Binds directly and phosphorylates the NADPH oxidase RBOHD at specific sites in a calcium-independent manner to enhance reactive oxygen species (ROS) generation upon flg22 perception. ROS production in response to flg22 controls stomatal movement and restriction of bacterial entry into leaf tissues (PubMed:24629339). Seems not required for flg22-induced MAPK activation (Probable). Required for Pep1-induced defenses. Pep1 is an endogenous elicitor that potentiates PAMP-inducible plant responses. In association with PEPR1, acts downstream of the canonical ethylene signaling cascade to regulate ethylene responses (PubMed:23431184). Involved in ethylene signaling. Destabilizes EIN3, the key transcription activator in ethylene signaling, and represses EIN3-dependent transcription (PubMed:26021844). Acts as a negative regulator in brassinosteroid (BR) signaling. Functions in BR signaling by direct interaction with the BR receptor BRI1 cytosolic kinase domain (PubMed:23818580).<ref>PMID:16339855</ref> <ref>PMID:20404519</ref> <ref>PMID:20413097</ref> <ref>PMID:23431184</ref> <ref>PMID:23818580</ref> <ref>PMID:24104392</ref> <ref>PMID:24629339</ref> <ref>PMID:26021844</ref> <ref>PMID:22504181</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Fisher, A J]]
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[[Category: Hurlburt, N K]]
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[[Category: Lal, N K]]
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[[Category: Bik1]]
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[[Category: Pamp-triggered immunity]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]

Revision as of 05:37, 18 April 2018

Botrytis-induced kinase 1 (BIK1) from Arabidopsis thaliana

5tos, resolution 2.35Å

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