5wkd

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'''Unreleased structure'''
 
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The entry 5wkd is ON HOLD until Paper Publication
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==Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306==
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<StructureSection load='5wkd' size='340' side='right' caption='[[5wkd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Guenther, E.L., Trinh, H., Sawaya, M.R., Cascio, D., Eisenberg, D.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wkd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WKD FirstGlance]. <br>
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Description: Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkd OCA], [http://pdbe.org/5wkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wkd RCSB], [http://www.ebi.ac.uk/pdbsum/5wkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkd ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Eisenberg, D.S]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[http://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cascio, D]]
[[Category: Cascio, D]]
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[[Category: Sawaya, M.R]]
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[[Category: Eisenberg, D S]]
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[[Category: Guenther, E.L]]
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[[Category: Guenther, E L]]
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[[Category: Sawaya, M R]]
[[Category: Trinh, H]]
[[Category: Trinh, H]]
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[[Category: Amyloid]]
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[[Category: Low complexity domain]]
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[[Category: Protein fibril]]
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[[Category: Tdp-43]]

Revision as of 05:39, 18 April 2018

Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306

5wkd, resolution 1.80Å

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