5z96

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m (Protected "5z96" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5z96 is ON HOLD
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==Structure of the mouse TRPC4 ion channel==
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<StructureSection load='5z96' size='340' side='right' caption='[[5z96]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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Authors: Duan, J., Li, Z., Li, J., Zhang, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5z96]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z96 FirstGlance]. <br>
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Description: Structure of the mouse TRPC4 ion channel
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z96 OCA], [http://pdbe.org/5z96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z96 RCSB], [http://www.ebi.ac.uk/pdbsum/5z96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z96 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPC4_MOUSE TRPC4_MOUSE]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.<ref>PMID:11175743</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Duan, J]]
[[Category: Duan, J]]
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[[Category: Li, J]]
[[Category: Li, Z]]
[[Category: Li, Z]]
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[[Category: Li, J]]
 
[[Category: Zhang, J]]
[[Category: Zhang, J]]
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[[Category: Cryoem]]
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[[Category: Membrane protein]]
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[[Category: Mouse full length trpc4]]

Revision as of 05:42, 18 April 2018

Structure of the mouse TRPC4 ion channel

5z96, resolution 3.28Å

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