5ttj
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first structure of nicotine oxidoreductase (NicA2) was determined by X-ray crystallography. Pseudomonas putida has evolved nicotine-degrading activity to provide a source of carbon and nitrogen. The structure establishes NicA2 as a member of the monoamine oxidase family. Residues 1-50 are disordered and may play a role in localization. The nicotine-binding site proximal to the isoalloxazine ring of flavin shows an unusual composition of the classical aromatic cage (W427 and N462). The active site architecture is consistent with the proposed binding of the deprotonated form of the substrate and the flavin-dependent oxidation of the pyrrolidone C-N bond followed by nonenzymatic hydrolysis. | ||
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| + | Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.,Tararina MA, Janda KD, Allen KN Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18. PMID:27933790<ref>PMID:27933790</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ttj" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:31, 18 April 2018
Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida
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