6enz
From Proteopedia
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<StructureSection load='6enz' size='340' side='right' caption='[[6enz]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='6enz' size='340' side='right' caption='[[6enz]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6enz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6enz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
+ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gadl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6enz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6enz OCA], [http://pdbe.org/6enz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6enz RCSB], [http://www.ebi.ac.uk/pdbsum/6enz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6enz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6enz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6enz OCA], [http://pdbe.org/6enz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6enz RCSB], [http://www.ebi.ac.uk/pdbsum/6enz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6enz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Pyridoxal 5'-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), which lacks the activity to decarboxylate glutamate to gamma-aminobutyrate, despite its homology to glutamic acid decarboxylase. Among the acidic amino acid decarboxylases, GADL1 is most similar to cysteine sulfinic acid decarboxylase (CSAD), but the physiological function of GADL1 is unclear, although its expression pattern and activity suggest a role in neurotransmitter and neuroprotectant metabolism. The crystal structure of mouse GADL1 is described, together with a solution model based on small-angle X-ray scattering data. While the overall fold and the conformation of the bound PLP are similar to those in other PLP-dependent decarboxylases, GADL1 adopts a more loose conformation in solution, which might have functional relevance in ligand binding and catalysis. The structural data raise new questions about the compactness, flexibility and conformational dynamics of PLP-dependent decarboxylases, including GADL1. | ||
+ | |||
+ | Structure of the mouse acidic amino acid decarboxylase GADL1.,Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):65-73. doi:, 10.1107/S2053230X17017848. Epub 2018 Jan 1. PMID:29372909<ref>PMID:29372909</ref> | ||
+ | |||
+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
+ | <div class="pdbe-citations 6enz" style="background-color:#fffaf0;"></div> | ||
+ | == References == | ||
+ | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Lk3 transgenic mice]] | ||
[[Category: Haavik, J]] | [[Category: Haavik, J]] | ||
[[Category: Kursula, P]] | [[Category: Kursula, P]] |
Revision as of 06:46, 18 April 2018
Crystal structure of mouse GADL1
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