2h6t
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2h6t |SIZE=350|CAPTION= <scene name='initialview01'>2h6t</scene>, resolution 1.900Å | |PDB= 2h6t |SIZE=350|CAPTION= <scene name='initialview01'>2h6t</scene>, resolution 1.900Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=IHN:3-HYDROXY-4-ISOBUTYL-4-[AMINOCARBONYLETHYL(AMINO+CARBONYL-2-HYDROXY-5-METHYLHEXYL)TRI(AMINOCARBONYL+ISOBUTYL)]BUTANOIC+ACID'>IHN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span> |
|GENE= SAP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans]) | |GENE= SAP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2h6s|2H6S]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h6t OCA], [http://www.ebi.ac.uk/pdbsum/2h6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h6t RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Maskos, K.]] | [[Category: Maskos, K.]] | ||
[[Category: Ruge, E.]] | [[Category: Ruge, E.]] | ||
| - | [[Category: IHN]] | ||
| - | [[Category: ZN]] | ||
[[Category: aspartic proteinase]] | [[Category: aspartic proteinase]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:26:14 2008'' |
Revision as of 00:26, 31 March 2008
| |||||||
| , resolution 1.900Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | SAP3 (Candida albicans) | ||||||
| Activity: | Candidapepsin, with EC number 3.4.23.24 | ||||||
| Related: | 2H6S
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A
Overview
The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C. albicans) infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures is crucial for inhibitor design; only the structure of Sap2 is known. We report the 1.9 and 2.2 A resolution X-ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme.
About this Structure
2H6T is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.
Reference
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Korting HC, Huber R, Maskos K, Proteins. 2007 Aug 15;68(3):738-48. PMID:17510964
Page seeded by OCA on Mon Mar 31 03:26:14 2008
