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Cytochrome P450
From Proteopedia
(Difference between revisions)
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**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | **[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | ||
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br /> | **[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br /> | ||
| - | **[[5a5i]], [[5a5j]] - hP4502C9 + inhibitor<br /> | + | **[[5xxi]], [[5x23]], [[5x24]] - hP4502C9 (mutant) + blood pressure drug<br /> |
| + | **[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br /> | ||
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br /> | **[[4nz2]] - hP4502C9 (mutant) + inhibitor<br /> | ||
**[[4gqs]] - hP4502C19 catalytic domain<br /> | **[[4gqs]] - hP4502C19 catalytic domain<br /> | ||
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* human P450 3 family | * human P450 3 family | ||
| + | **[[5vcc]], [[5vcd]] - hP4503A4 (mutant) <br /> | ||
**[[2v0m]] – hP4503A4+ anti-fungal drug<br /> | **[[2v0m]] – hP4503A4+ anti-fungal drug<br /> | ||
**[[2j0d]] - hP4503A4+ antibiotic<br /> | **[[2j0d]] - hP4503A4+ antibiotic<br /> | ||
**[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br /> | **[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br /> | ||
| - | **[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]] - hP4503A4 (mutant) + anti-HIV drug<br /> | + | **[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]], [[5vc0]], [[5vce]] - hP4503A4 (mutant) + anti-HIV drug<br /> |
| + | **[[5g5j]] - hP4503A4 + anti-diabetic drug<br /> | ||
**[[3ua1]] - hP4503A4 + ergocryptine<br /> | **[[3ua1]] - hP4503A4 + ergocryptine<br /> | ||
| + | **[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | ||
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br /> | **[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br /> | ||
**[[4i3q]] - hP4503A4 (mutant) <br /> | **[[4i3q]] - hP4503A4 (mutant) <br /> | ||
| - | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]] - hP4503A4 + inhibitor <br /> | + | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]] - hP4503A4 + inhibitor <br /> |
**[[5te8]] - hP4503A4 + sedation drug <br /> | **[[5te8]] - hP4503A4 + sedation drug <br /> | ||
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | **[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | ||
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**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br /> | **[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br /> | ||
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br /> | **[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br /> | ||
| - | **[[3a4z]] - PaP450 VDH (mutant)<br /> | + | **[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br /> |
**[[3qi8]] – P450 – synthetic<br /> | **[[3qi8]] – P450 – synthetic<br /> | ||
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br /> | **[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br /> | ||
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**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | **[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | ||
**[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | **[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | ||
| + | **[[5x7e]] - SsP450 CYP105A1 (mutant)+vitamin D2<br /> | ||
**[[5fsa]] – P450 CYP51 (mutant) + posaconazole - ''Candida albicans''<br /> | **[[5fsa]] – P450 CYP51 (mutant) + posaconazole - ''Candida albicans''<br /> | ||
**[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD <br /> | **[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD <br /> | ||
Revision as of 10:47, 18 April 2018
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3D Structures of Cytochrome P450
Updated on 18-April-2018
References
- ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
- ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862
