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Sandbox GGC7

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== Function ==
== Function ==
<scene name='Sandbox_GGC7/Active_glu137_his89_lys9/null'>Active Site</scene>
<scene name='Sandbox_GGC7/Active_glu137_his89_lys9/null'>Active Site</scene>
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It is unclear if there is a normal function of this protein, but there is research suggesting it plays a role in neural development (1).
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It is unclear if there is a normal function of human trypsin IV, but there is research suggesting that it has a role in neural development (1). However, it is mostly associated with neurodegenerative diseases such as Alzheimer’s (2). It is found in glial cells and astrocytes (2). It breaks down proteins in the brain and forms protein aggregates called amyloids (2). These sticky structures eventually harden and form plaque.
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One of this protein’s original residues changes to form the version of the protein that causes Alzheimer’s, dementia, and other mental disorders (1,2). Its 193rd residue is Glycine, but when it becomes Arginine, it disrupts normal activity (2). There are inhibitors in the brain that block this protein, but the version with Arg193 causes steric hindrance in the active site of its inhibitor (2). Another feature of this protein that is problematic is its positive charge, which also interferes with the inhibitor (2).
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Revision as of 20:23, 21 April 2018

Structure of Brain Trypsin (human trypsin IV)

Triose phosphate isomerase

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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