We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Sandbox GGC7
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
This is a default text for your page '''Sandbox GGC7'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Sandbox GGC7'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| + | |||
| + | Human Trypsin IV is a proteinase (1). Trypsins are mainly found in the pancreas and aid in food digestion; however, there are other trypsins that are present in the human brain and are homologous to those found in other animals such as mice (1). | ||
== Function == | == Function == | ||
<scene name='Sandbox_GGC7/Active_glu137_his89_lys9/null'>Active Site</scene> | <scene name='Sandbox_GGC7/Active_glu137_his89_lys9/null'>Active Site</scene> | ||
| - | It is unclear if there is a normal function of this protein, but there is research suggesting it plays a role in neural development (1). | + | It is mostly associated with disease and abnormal function in the brain. It is unclear if there is a normal function of this protein, but there is research suggesting it plays a role in neural development (1).It is associated with neurodegenerative diseases such as Alzheimer's, and possibly dementia (2). It is found in glial cells and astrocytes (2). It breaks down proteins in the brain and forms aggregates called amyloids (2). These sticky structures harden and form plaque (2). |
| - | + | ||
Revision as of 20:35, 21 April 2018
Structure of Brain Trypsin (human trypsin IV)
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
