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Cytochrome P450
From Proteopedia
(Difference between revisions)
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* P450cam | * P450cam | ||
| - | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]] – PpP450cam(mutant) – ''Pseudomona putida''<br /> | + | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]] – PpP450cam(mutant) – ''Pseudomona putida''<br /> |
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam<br /> | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam<br /> | ||
**[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | **[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | ||
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**[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br /> | **[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br /> | ||
**[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br /> | **[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br /> | ||
| - | **[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]] - PpP450cam (mutant)+ camphor + CN<br /> | + | **[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]], [[5wk9]] - PpP450cam (mutant)+ camphor + CN<br /> |
**[[4kky]] - PpP450cam (mutant)+ camphor + pyrene derivative<br /> | **[[4kky]] - PpP450cam (mutant)+ camphor + pyrene derivative<br /> | ||
**[[2l8m]] – PpP450cam+camphor+CO<br /> | **[[2l8m]] – PpP450cam+camphor+CO<br /> | ||
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**[[4c9o]] - NaP450cam (mutant) + camphor + CN<br /> | **[[4c9o]] - NaP450cam (mutant) + camphor + CN<br /> | ||
| - | * P450nor | + | * P450nor or NADP nitrous oxide-forming nitric-oxide reductase or nitric oxide reductase |
| - | **[[1cl6]], [[1rom]] – FoP450nor - ''Fusarium oxysporum''<br /> | + | **[[1cl6]], [[1rom]], [[5y5j]], [[5y5l]], [[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] – FoP450nor - ''Fusarium oxysporum''<br /> |
**[[2rom]] - FoP450nor+CO<br /> | **[[2rom]] - FoP450nor+CO<br /> | ||
| - | **[[1cmj]], [[1cmn]], [[1ehg]] - FoP450nor (mutant)<br /> | + | **[[5y5f]], [[5y5g]], [[5y5h]], [[5y5k]] – FoP450nor + NO<br /> |
| + | **[[1f24]], [[1f25]], [[1f26]] – FoP450nor (mutant) + NO<br /> | ||
| + | **[[5y5i]] – FoP450nor + NO + NADH<br /> | ||
| + | **[[1cmj]], [[1cmn]], [[1ehg]], [[1ehf]], [[1ulw]] - FoP450nor (mutant)<br /> | ||
**[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br /> | **[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br /> | ||
| - | **[[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] - FoP450nor<br /> | ||
**[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br /> | **[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br /> | ||
| - | **[[1ulw]] - FoP450nor (mutant) | ||
*P450epoK | *P450epoK | ||
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**[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br /> | **[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br /> | ||
**[[4lht]], [[4l77]] - CbP450cin (mutant)<br /> | **[[4lht]], [[4l77]] - CbP450cin (mutant)<br /> | ||
| - | **[[4fmx]] – CbP450cin + cineole<br /> | + | **[[4fmx]], [[1t2b]] – CbP450cin + cineole<br /> |
**[[4l6g]] – CbP450cin (mutant) + cineole<br /> | **[[4l6g]] – CbP450cin (mutant) + cineole<br /> | ||
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**[[1n6b]] - rP450 CYP2C5+sulfaphenazole | **[[1n6b]] - rP450 CYP2C5+sulfaphenazole | ||
| - | *P450 BM3 | + | *P450 BM3 or bifunctional P450/NADPH-P450 reductase |
| - | **[[3cbd]], [[2bmh]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | + | **[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]] – BmP450 heme domain – ''Bacillus megaterium''<br /> |
| - | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]] - BmP450 heme domain (mutant)<br /> | + | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br /> |
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | **[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | ||
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | **[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | ||
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**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | **[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | ||
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | **[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | ||
| - | **[[4kew]], [[4key]], [[4o4p]] - BmP450 heme domain (mutant) + | + | **[[4kew]], [[4key]], [[4o4p]], [[4zf8]] - BmP450 heme domain (mutant) + drug<br /> |
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | **[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | ||
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | **[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | ||
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**[[3ben]] - BmP450 heme domain + inhibitor<br /> | **[[3ben]] - BmP450 heme domain + inhibitor<br /> | ||
**[[2j1m]] - BmP450102 heme domain +DMSO<br /> | **[[2j1m]] - BmP450102 heme domain +DMSO<br /> | ||
| + | **[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br /> | ||
**[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br /> | **[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br /> | ||
| - | **[[1fag]] – BmP450102A1+ | + | **[[5e78]] - BmP450 + Co + sepulchrate<br /> |
| + | **[[1fag]] – BmP450102A1+ palmitate<br /> | ||
| + | **[[4zfb]], [[5dyz]] - BmP450 (mutant) + palmitate<br /> | ||
| + | **[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 + amino acid derivative<br /> | ||
| + | **[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 (mutant) + tryptophan derivative<br /> | ||
**[[4yt3]] - BmP450 CYP106A2 <br /> | **[[4yt3]] - BmP450 CYP106A2 <br /> | ||
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br /> | **[[5iki]] - BmP450 CYP106A2 + abietic acid <br /> | ||
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**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br /> | **[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br /> | ||
**[[5liv]] - ScP450 CYP260A1 <br /> | **[[5liv]] - ScP450 CYP260A1 <br /> | ||
| + | **[[6f85]] - ScP450 CYP260A1 (mutant)<br /> | ||
**[[5hiw]] - ScP450 CYP260B1 <br /> | **[[5hiw]] - ScP450 CYP260B1 <br /> | ||
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | **[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | ||
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**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | **[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | ||
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br /> | **[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br /> | ||
| - | + | **[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br /> | |
| + | **[[6f8a]] - ScP450 CYP260A1 (mutant) + histidine<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:38, 22 April 2018
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3D Structures of Cytochrome P450
Updated on 22-April-2018
References
- ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
- ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862
