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==5YPI Mechanism of NDM-1== | ==5YPI Mechanism of NDM-1== | ||
<StructureSection load='5YPI' size='340' side='right' caption='Caption for this structure' scene='/78/781194/5ypi-1/1'> | <StructureSection load='5YPI' size='340' side='right' caption='Caption for this structure' scene='/78/781194/5ypi-1/1'> | ||
| + | The 5YPI structure contains 14,682 atoms, 14,184 bonds, 2729 groups, and 8 chains. | ||
New Delhi metallo-beta-lactamases (NDMs), pose a serious threat due to their extremely efficient mechanism of hydrolysis on beta-lactam antibiotics. These antibiotics target the penicillin-binding proteins in enzymes found anchored in the cell membrane, which are involved in the cross-linking of the bacterial cell wall. The beta-lactam ring binds to different penicillin-binding proteins making them unable to do cell wall synthesis which leads to death of the bacterial cell. The NDM-1 gene causes the bacterium to produce an enzyme that neutralizes even the strongest antibiotics family: (Carbapenems) imipenem is in that family and only used as last resort.The antibiotics strain that carries the NDM-1 gene are so dangerous because we have no way to combat them. | New Delhi metallo-beta-lactamases (NDMs), pose a serious threat due to their extremely efficient mechanism of hydrolysis on beta-lactam antibiotics. These antibiotics target the penicillin-binding proteins in enzymes found anchored in the cell membrane, which are involved in the cross-linking of the bacterial cell wall. The beta-lactam ring binds to different penicillin-binding proteins making them unable to do cell wall synthesis which leads to death of the bacterial cell. The NDM-1 gene causes the bacterium to produce an enzyme that neutralizes even the strongest antibiotics family: (Carbapenems) imipenem is in that family and only used as last resort.The antibiotics strain that carries the NDM-1 gene are so dangerous because we have no way to combat them. | ||
== Function == Hydrolase | == Function == Hydrolase | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | https://rdcu.be/MgiZ | ||
Revision as of 15:24, 22 April 2018
5YPI Mechanism of NDM-1
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