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Sandbox GGC12
From Proteopedia
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== Function == | == Function == | ||
| - | Cytokines are protein growth factors that play a role in numerous cellular activities, primarily white blood cell response. IL-6 is a cytokine known to have many functions which include stimulating cells that give rise to blood cells and cells that function in the immune system. IL-6 aids in the antibody-mediated immunity component of the adaptive immune system by targeting cells that secrete antibodies such as B lymphocytes. It also plays in cell-mediated immunity by targeting cells such as T lymphocytes. It turns and enhances the colony of cells producing blood cells. It also aids in the production of the proteins that flux in plasma concentration in response to inflammation, which are known as acute phase response proteins. | + | Cytokines are protein growth factors that play a role in numerous cellular activities, primarily white blood cell response. IL-6 is a cytokine known to have many functions which include stimulating cells that give rise to blood cells and cells that function in the immune system.<ref>Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.</ref> IL-6 aids in the antibody-mediated immunity component of the adaptive immune system by targeting cells that secrete antibodies such as B lymphocytes. It also plays in cell-mediated immunity by targeting cells such as T lymphocytes. It turns and enhances the colony of cells producing blood cells. It also aids in the production of the proteins that flux in plasma concentration in response to inflammation, which are known as acute phase response proteins. |
== Disease == | == Disease == | ||
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<scene name='78/781196/Disulfide_linkage_aandb/2'>Here you are able to get a clear view of the disulfide linkage between Helix A and Helix B. </scene> | <scene name='78/781196/Disulfide_linkage_aandb/2'>Here you are able to get a clear view of the disulfide linkage between Helix A and Helix B. </scene> | ||
| - | + | There are water molecules throughout the IL-6 structure that form a network of hydrogen bonds that stabilize the molecule's structure. | |
<scene name='78/781196/View_of_the_water_structure/1'>Here you are able to get a view of the water structure in the region between the D helix and the A-B loop of IL-6. </scene> | <scene name='78/781196/View_of_the_water_structure/1'>Here you are able to get a view of the water structure in the region between the D helix and the A-B loop of IL-6. </scene> | ||
Revision as of 23:52, 22 April 2018
Structure: Human Interleukin-6
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
