Adapter molecule crk

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== Structural highlights ==
== Structural highlights ==
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Crk domains include several N-terminal SH2 and C-terminal SH3 domains. <scene name='57/573988/Cv/2'>Mouse Crk N terminal SH3 domain complex with proline-rich peptide</scene> ([[1cka]])<ref>PMID:7735837</ref> is shown.
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Crk domains include several N-terminal SH2 and C-terminal SH3 domains. <scene name='57/573988/Cv/3'>Mouse Crk N terminal SH3 domain complex with proline-rich peptide</scene> ([[1cka]])<ref>PMID:7735837</ref> is shown.
</StructureSection>
</StructureSection>

Revision as of 14:24, 23 April 2018

Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry 1cka)

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3D structures of adpter molecule crk

Updated on 23-April-2018

1m30, 1m3a, 1m3b, 1m3c – mCrk N terminal SH3 (mutant) – mouse - NMR
2ggr – mCrk C terminal SH3 - NMR
2l3p, 2l3q, 2l3s – Crk residues 220-297 – chicken – NMR
1cka, 1ckb, 5ih2 – mCrk N terminal SH3 + proline-rich peptide
5l23 – mCrk N terminal SH3 + proline-rich peptide - NMR
1b07 – mCrk N terminal SH3 + SH3 peptoid inhibitor
5jn0 – hCrk SH2 - human
1ju5 – hCrk SH2 + phosphopeptide + Abl SH3
5ul6 – hCrk residues 134-191 + influenza virus proline-rich motif

References

  1. ↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608
  2. ↑ Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

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Michal Harel, Alexander Berchansky

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