Sandbox GGC6

3BAJ is used in a lot of studies that have to do with allosteric activiation of human pancreatic alpha-amylase via chloride ions. It's primarily used as a anion substitution by using kinetic and structural experimentations. It's also composed of extracellular exosome which is a vesicle that is released by the extracellular region through fusion of limiting endosomal membranes of multivesicular bodies within the plasma membrane. ^[1] or to the article describing Jmol ^[2].

Function

Its biochemical function is an Alpha-amylase activator that allows for the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. It also has a biological process of polysaccharide digestion which is a biochemical, chemical, and physical process that is carried out by living organisms to break down ingested polysaccharides into components that can be easily directed and absorbed into metabolism.

Disease

No diseases have been found to be associated with this. It's primarily used in experiments but it is found in homo sapiens

Relevance

This is one type of major molecule that is used as an alternative anion which can induce some level of enzymatic activity despite very different atomic geometries, sizes, and polyatomic natures

Structural highlights

Secondary structure of the 3BAJ shows the alpha and beta helix sheets</scene> This is a view of the only found in 3BAJ The ligand is composed of NO3

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644