Adenosine deaminase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | There are 2 isoforms of ADA: ADA1 and ADA2. <scene name='54/547081/Cv/ | + | There are 2 isoforms of ADA: ADA1 and ADA2. <scene name='54/547081/Cv/3'>ADA contains Zn+2 ion in its active site</scene> ([[2pgf]]).<ref>PMID:18602399</ref> Water mlecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:37, 24 April 2018
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3D Structures of adenosine deaminase
Updated on 24-April-2018
References
- ↑ Wilson DK, Rudolph FB, Quiocho FA. Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Science. 1991 May 31;252(5010):1278-84. PMID:1925539
- ↑ Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol. 2008 Sep 12;381(4):975-88. Epub 2008 Jun 24. PMID:18602399 doi:http://dx.doi.org/10.1016/j.jmb.2008.06.048
