6f4z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==2'F-araG modified quadruplex with flipped G-tract and central tetrad== | |
| + | <StructureSection load='6f4z' size='340' side='right' caption='[[6f4z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6f4z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F4Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f4z OCA], [http://pdbe.org/6f4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f4z RCSB], [http://www.ebi.ac.uk/pdbsum/6f4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f4z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A (3+1)-hybrid-type G-quadruplex was substituted within its central tetrad by a single 2'-fluoro-modified guanosine. Driven by the anti-favoring nucleoside analogue, a novel quadruplex fold with inversion of a single G-tract and conversion of a propeller loop into a lateral loop emerges. In addition, scalar couplings across hydrogen bonds demonstrate the formation of intra- and inter-residual FH8-C8 pseudo-hydrogen bonds within the modified quadruplexes. Alternative folding can be rationalized by the impact of fluorine on intermediate species on the basis of a kinetic partitioning mechanism. Apparently, chemical or other environmental perturbations are able to redirect folding of a quadruplex, possibly modulating its regulatory role in physiological processes. | ||
| - | + | Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway.,Dickerhoff J, Weisz K Chembiochem. 2018 Feb 20. doi: 10.1002/cbic.201800099. PMID:29460996<ref>PMID:29460996</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 6f4z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dickerhoff, J]] | [[Category: Dickerhoff, J]] | ||
[[Category: Weisz, K]] | [[Category: Weisz, K]] | ||
| + | [[Category: 2'f-ana]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: G-quadruplex]] | ||
Revision as of 05:37, 25 April 2018
2'F-araG modified quadruplex with flipped G-tract and central tetrad
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Categories: Dickerhoff, J | Weisz, K | 2'f-ana | Dna | G-quadruplex
