We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
6gaj
From Proteopedia
(Difference between revisions)
m (Protected "6gaj" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)== | |
| - | + | <StructureSection load='6gaj' size='340' side='right' caption='[[6gaj]], [[Resolution|resolution]] 1.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gaj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GAJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gaj OCA], [http://pdbe.org/6gaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gaj RCSB], [http://www.ebi.ac.uk/pdbsum/6gaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gaj ProSAT]</span></td></tr> |
| - | [[Category: Dietrich, M | + | </table> |
| - | [[Category: Stehle, | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dietrich, M H]] | ||
| + | [[Category: Stehle, T]] | ||
| + | [[Category: Cell attachment protein]] | ||
| + | [[Category: Coiled coil]] | ||
| + | [[Category: Reovirus sigma1]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 05:39, 25 April 2018
Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)
| |||||||||||
