Dihydroorotate dehydrogenase

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Line 34: Line 34:
**[[1jqv]], [[1jqx]], [[1jrb]], [[1jrc]], [[1ovd]] – LlDHOD A (mutant) + orotate <br />
**[[1jqv]], [[1jqx]], [[1jrb]], [[1jrc]], [[1ovd]] – LlDHOD A (mutant) + orotate <br />
**[[2bsl]], [[2bx7]] – LlDHOD A + pyrimidine analog <br />
**[[2bsl]], [[2bx7]] – LlDHOD A + pyrimidine analog <br />
-
**[[1ep2]] – LlDHOD B+ orotate <br />
+
**[[1ep2]], [[1ue9]] – LlDHOD B+ orotate <br />
**[[2djl]] – TcDHOD + succinate <br />
**[[2djl]] – TcDHOD + succinate <br />
**[[2e6a]] - TcDHOD + orotate derivative<br />
**[[2e6a]] - TcDHOD + orotate derivative<br />
Line 42: Line 42:
**[[2bxv]] – hDHOD + orotate<br />
**[[2bxv]] – hDHOD + orotate<br />
**[[2e68]] – hDHOD + dihydroorotate<br />
**[[2e68]] – hDHOD + dihydroorotate<br />
-
**[[2b4g]] – DHOD + orotate – ''Trypanosoma brucei''<br />
+
**[[2b4g]] – TbDHOD + orotate – ''Trypanosoma brucei''<br />
**[[3c61]] – DHOD + orotate – ''Leishmania donovani''<br />
**[[3c61]] – DHOD + orotate – ''Leishmania donovani''<br />
**[[3mhu]], [[3mjy]] – LmDHOD + orotate derivative <br />
**[[3mhu]], [[3mjy]] – LmDHOD + orotate derivative <br />
Line 55: Line 55:
**[[4igh]] - hDHODH + quinoline derivative<br />
**[[4igh]] - hDHODH + quinoline derivative<br />
**[[3f1q]], [[3fj6]], [[3fjl]], [[3g0u]], [[3g0x]] – hDHODH + orotate + leflunomide<br />
**[[3f1q]], [[3fj6]], [[3fjl]], [[3g0u]], [[3g0x]] – hDHODH + orotate + leflunomide<br />
-
**[[3w7r]], [[3u2o]], [[3zws]], [[3zwt]], [[4jgd]], [[4js3]], [[4jts]], [[1d3g]], [[1uuo]], [[2b0m]], [[2fpt]], [[2fpv]], [[2fpy]], [[2fqi]], [[2wv8]], [[4jtt]], [[4jtu]], [[4ls0]], [[4ls1]], [[4ls2]], [[4oqv]], [[4rk8]], [[4rka]], [[4rli]], [[4rr4]], [[4ylw]], [[4zl1]], [[4zmg]], [[5h2z]], [[5hin]], [[5hqe]], [[5k9c]], [[5k9d]], [[5mut]], [[5mvc]], [[5mvd]] – hDHODH + orotate + inhibitor<br />
+
**[[3w7r]], [[3u2o]], [[3zws]], [[3zwt]], [[4jgd]], [[4js3]], [[4jts]], [[1d3g]], [[1uuo]], [[2b0m]], [[2fpt]], [[2fpv]], [[2fpy]], [[2fqi]], [[2wv8]], [[4jtt]], [[4jtu]], [[4ls0]], [[4ls1]], [[4ls2]], [[4oqv]], [[4rk8]], [[4rka]], [[4rli]], [[4rr4]], [[4ylw]], [[4zl1]], [[4zmg]], [[5h2z]], [[5hin]], [[5hqe]], [[5k9c]], [[5k9d]], [[5mut]], [[5mvc]], [[5mvd]], [[5h73]] – hDHODH + orotate + inhibitor<br />
**[[2prl]], [[2prm]], [[2prh]] – hDHODH (mutant) + orotate + inhibitor<br />
**[[2prl]], [[2prm]], [[2prh]] – hDHODH (mutant) + orotate + inhibitor<br />
 +
**[[6et4]] – hDHODH + FMN + inhibitor<br />
**[[4ori]] – rDHODH + orotate + inhibitor - rat<br />
**[[4ori]] – rDHODH + orotate + inhibitor - rat<br />
**[[1uum]] – rDHODH + orotate + drug<br />
**[[1uum]] – rDHODH + orotate + drug<br />
**[[1tv5]], [[3i65]], [[3i68]], [[3i6r]], [[3o8a]], [[3sfk]], [[4cq8]], [[4cq9]], [[4cqa]], [[4orm]], [[4rx0]], [[5boo]], [[5fi8]] – PfDHODH + orotate + inhibitor – ''Plasmodium falciparum''<br />
**[[1tv5]], [[3i65]], [[3i68]], [[3i6r]], [[3o8a]], [[3sfk]], [[4cq8]], [[4cq9]], [[4cqa]], [[4orm]], [[4rx0]], [[5boo]], [[5fi8]] – PfDHODH + orotate + inhibitor – ''Plasmodium falciparum''<br />
**[[5del]], [[5tbo]] – PfDHODH (mutant) + orotate + inhibitor <br />
**[[5del]], [[5tbo]] – PfDHODH (mutant) + orotate + inhibitor <br />
 +
**[[6b8s]] – DHODH + FMN – ''Helicobacter pylori''<br />
* Dihydroorotate dehydrogenase (fumarate)
* Dihydroorotate dehydrogenase (fumarate)
Line 67: Line 69:
**[[3w1p]] - TcDHODF + pyrimidine derivative<br />
**[[3w1p]] - TcDHODF + pyrimidine derivative<br />
**[[3w1a]], [[3w1l]], [[3w1m]], [[3w1n]] - TcDHODF + orotate derivative<br />
**[[3w1a]], [[3w1l]], [[3w1m]], [[3w1n]] - TcDHODF + orotate derivative<br />
 +
**[[5xfw]] - TbDHODF (mutant) + malonate<br />
 +
**[[5xfv]] - TbDHODF (mutant) + FMN + malonate<br />
}}
}}

Revision as of 10:37, 26 April 2018

Human dihydroorotate dehydrogenase with FMN complex with orotate and inhibitor brequinar (PDB entry 2b0m)

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3D Structures of dihydroorotate dehydrogenase

Updated on 26-April-2018

References

  1. ↑ Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL. On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. PMID:23452331 doi:http://dx.doi.org/10.1021/jm301848w
  2. ↑ Hurt DE, Sutton AE, Clardy J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. Epub 2006 Jan 10. PMID:16406782 doi:S0960-894X(05)01599-4

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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