Sandbox GGC10

Function

When eating, all your senses are functioning. The digestive system is preparing for the incoming food. After the eating process is complete, the final step is a signal in the stomach that stimulates the medula ablongada. Then, that signals the body to allow the hormone gastrin to work (hormone that inhibits the stomach to release its gastric juices). Gastric juice is converted pepsinogen into pepsin by removing some amino acids. Pepsin then will do its job by aiding to digest what have been intake.

Disease

There many diseases associated with Human pepsin. For instance, peptic ulcers are very common. It is a condition when there is soreness in the lining of the stomach, small intestine, and the esophagus. There are 2 types of peptic ulcers which include gastric ulcers that happens inside the stomach and duodenal ulcers that occurs in the inside of the small intestine. The common cause of peptic ulcer is an infection with the bacterium Helicobacter pylori. Some symptoms can be stomach pain, nausea, and heartburn. It is recommended to see a doctor when someone is experiencing severe signs.

Relevance

Pepsin is considered a powerful enzyme found in the stomach of humans and other animals. It helps breakdown and digest proteins into small peptides like meat, seeds, eggs, or dairy products. It is produced by the human gastric mucosa. Pepsin is in complex with pepstatin. It is a very important enzyme, hence one of the first enzymes to be discovered.

Structural highlights

The region of the pepstatin molecule show with the residues. Ala,Iva, and residues as well as Sta terminal are low on density. They must generate new conformations since the model can't fit

A protein inhibitor forms an extended conformation with the first hydroxyl oxygen located in the active sites between carboxyl groups Asp 32 and Asp 215

The structure of Human Pepsin is similar to a serine Endoproteinase with molecular weight of 35 kd. the structure is divided into 3 domains. The main domain includes 6 stranded antiparallel beta sheet that helps as a backbone to the active site region. It is comprisedThe N-terminal is also composed of residues