User:Andrea Foote/Sandbox 1
From Proteopedia
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==Purine-rich element binding protein alpha== | ==Purine-rich element binding protein alpha== | ||
| - | <StructureSection load='5fgp' size='340' side='right' caption='''Drosophila | + | <StructureSection load='5fgp' size='340' side='right' caption='''Drosophila Purα intramolecular domain (purple: PUR repeat I, orange: PUR repeat II) in complex with DNA (green). X-ray diffraction, 2Å resolution ([[5fgp]]).''' scene='78/786627/5fgp_intro/8'> |
== Introduction == | == Introduction == | ||
'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to recognize and bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, including cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ____. It plays a crucial role in nervous system development, and additionally is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | '''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to recognize and bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, including cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ____. It plays a crucial role in nervous system development, and additionally is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | ||
Revision as of 21:25, 27 April 2018
Purine-rich element binding protein alpha
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References
- ↑ Weber J, Bao H, Hartlmuller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Elife. 2016 Jan 8;5. pii: e11297. doi: 10.7554/eLife.11297. PMID:26744780 doi:http://dx.doi.org/10.7554/eLife.11297
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
