User:Khadar Abdi/Sandbox1
From Proteopedia
(Difference between revisions)
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== Introduction == | == Introduction == | ||
| - | '''Threonyl t-RNA Synthetase''' or '''Threonyl-tRNA ligase''' or '''TARS''' is a homodimer (150kDa in bacteria and 170kDa in human) and is classified as a class II '''Aminoacyl-tRNA synthetase''' enzymes. These ancient enzymes primary function are to add the respective amino acid to the respective transfer Ribonucleic Acid (tRNA-AA), a necessity prep for the protein synthesis pathway<ref>PMID:29305884</ref>. As the name implies, TARS function is to add Threonine amino acid (Thr) to threonine specific tRNA (tRNA-thr) in the presence of Adenosine triphosphate (ATP) and diavalent metal cation. Below displays the overview of TARS Aminoacylation rxn<ref>PMID:29305884</ref>.[[Image:TARS_protein_rxn.jpeg |center|thumb|400px| '''Overall TARS protein rxn. Substrates includes ATP, Thr and tRNA-thr.''']] | + | '''Threonyl t-RNA Synthetase''' or '''Threonyl-tRNA ligase''' or '''TARS''' is a homodimer (150kDa in bacteria and 170kDa in human) and is classified as a class II '''Aminoacyl-tRNA synthetase''' enzymes. These ancient enzymes primary function are to add the respective amino acid to the respective transfer Ribonucleic Acid (tRNA-AA), a necessity prep for the protein synthesis pathway<ref>PMID:29305884</ref>. As the name implies, TARS function is to add Threonine amino acid (Thr) to threonine specific tRNA (tRNA-thr) in the presence of Adenosine triphosphate (ATP) and diavalent metal cation. Below displays the overview of TARS Aminoacylation rxn<ref>PMID:29305884</ref>.[[Image:TARS_protein_rxn.jpeg |center|thumb|400px| '''Overall TARS protein rxn. Substrates includes ATP, Thr and tRNA-thr.''']] |
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==Mechanism== | ==Mechanism== | ||
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== Structural highlights== | == Structural highlights== | ||
| + | As mentioned earlier, TARS is homodimer protein. The protein is mainly classified as a alpha beta protein | ||
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== Evolutionary related proteins == | == Evolutionary related proteins == | ||
Revision as of 01:55, 29 April 2018
Threonyl-tRNA Synthetase/ligase
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