DNA glycosylase

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Line 59: Line 59:
**[[1lqj]] – EcUDG<BR />
**[[1lqj]] – EcUDG<BR />
**[[1flz]] - EcUDG (mutant) <BR />
**[[1flz]] - EcUDG (mutant) <BR />
-
**[[1udh]], [[1udg]] – HsUDG - Herpes simplex virus<BR />
+
**[[1udh]], [[1udg]], [[5nnh]], [[5nn7]] – HsUDG - Herpes simplex virus<BR />
**[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
**[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
**[[2c2q]] – DrUDG (mutant) <BR />
**[[2c2q]] – DrUDG (mutant) <BR />
Line 67: Line 67:
**[[3zor]] – BsUDG – ''Bacillus subtilis''<br />
**[[3zor]] – BsUDG – ''Bacillus subtilis''<br />
**[[4zbx]], [[4zbz]] – StUDG – ''Sulfolobus tokodaii'' <br />
**[[4zbx]], [[4zbz]] – StUDG – ''Sulfolobus tokodaii'' <br />
 +
**[[5x3g]] – NsUDG – ''Nitratifactor salsuginis''<br />
 +
**[[5x3h]] – NsUDG (mutant)<br />
*Uracil-DNA glycosylase complex with inhibitor protein
*Uracil-DNA glycosylase complex with inhibitor protein
Line 93: Line 95:
**[[4qcb]] – VvUDG (mutant) + DNA<br />
**[[4qcb]] – VvUDG (mutant) + DNA<br />
**[[2ddg]], [[2dem]], [[2dp6]] – TtUDG + DNA + deoxyphosphono ribose<br />
**[[2ddg]], [[2dem]], [[2dp6]] – TtUDG + DNA + deoxyphosphono ribose<br />
 +
**[[5nnu]] – HhUDG + DNA <br />
*Uracil-DNA glycosylase complex with uracil derivatives
*Uracil-DNA glycosylase complex with uracil derivatives
Line 175: Line 178:
**[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]], [[3uby]] – hAlkDG + DNA<BR />
**[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]], [[3uby]] – hAlkDG + DNA<BR />
**[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
**[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
 +
**[[5uuh]], [[5uug]], [[5uuf]], [[5kub]] – BcAlkDG + damaged DNA <br />
**[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
**[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
**[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
**[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
Line 182: Line 186:
**[[4aia]] – SaAlkDG + methyladenine<br />
**[[4aia]] – SaAlkDG + methyladenine<br />
**[[4ai5]] – SaAlkDG (mutant) + methyladenine<br />
**[[4ai5]] – SaAlkDG (mutant) + methyladenine<br />
 +
 +
*Alkylpurine DG
 +
 +
**[[5vi0]] – PfAlkCDG + DNA – ''Pseudomonas fluorescens''<br />
 +
**[[5vhv]] – PfAlkCDG + damaged DNA <br />
 +
*Formamidopyrimidine DG
*Formamidopyrimidine DG
Line 192: Line 202:
**[[1k82]] – EcFpg + DNA <br />
**[[1k82]] – EcFpg + DNA <br />
-
**[[1kfv]], [[1nnj]] – LlFpg (mutant) + DNA – ''Lactococcus lactis''<br />
+
**[[4pdi]], [[4pdg]], [[4pd2]], [[4pcz]] – LlFpg + damaged DNA – ''Lactococcus lactis''<br />
 +
**[[1kfv]], [[1nnj]] – LlFpg (mutant) + DNA <br />
**[[1l1t]], [[1l1z]], [[1l2b]], [[1l2c]] – GsFpg + DNA <br />
**[[1l1t]], [[1l1z]], [[1l2b]], [[1l2c]] – GsFpg + DNA <br />
**[[2f5n]], [[2f5o]], [[2f5p]], [[3gpx]], [[3gq5]] – GsFpg (mutant) + DNA <br />
**[[2f5n]], [[2f5o]], [[2f5p]], [[3gpx]], [[3gq5]] – GsFpg (mutant) + DNA <br />

Revision as of 09:40, 29 April 2018

Structure of adenine DNA glycosylase containing Fe4S4 cluster complex with DNA containing an oxoG base, deoxy-ribofuranose phosphate and Ca+2 ion (green) (PDB code 1rrs).

Drag the structure with the mouse to rotate

3D Structures of DNA glycosylate

Updated on 29-April-2018


References

  1. Fromme JC, Banerjee A, Verdine GL. DNA glycosylase recognition and catalysis. Curr Opin Struct Biol. 2004 Feb;14(1):43-9. PMID:15102448 doi:http://dx.doi.org/10.1016/j.sbi.2004.01.003
  2. Willetts KE, Rey F, Agostini I, Navarro JM, Baudat Y, Vigne R, Sire J. DNA repair enzyme uracil DNA glycosylase is specifically incorporated into human immunodeficiency virus type 1 viral particles through a Vpr-independent mechanism. J Virol. 1999 Feb;73(2):1682-8. PMID:9882380
  3. Fromme JC, Banerjee A, Huang SJ, Verdine GL. Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature. 2004 Feb 12;427(6975):652-6. PMID:14961129 doi:10.1038/nature02306

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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