Sandbox Reserved 1447
From Proteopedia
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== Introduction == | == Introduction == | ||
- | + | The von Willebrand Factor (VWF), observed by physician Erik von Willebrand, plays an important role in stopping the flow of blood. Hemostasis is the first step in healing a wound and is crucial for blood vessel repair. Located on chromosome 12, VWF interacts with functional domains such as the vascular wall, coagulation factor VIII, and platelet receptors. | |
== Function == | == Function == | ||
- | + | Upon a vascular injury, such as a paper cut, the von Willebrand factor binds to receptors on platelets, particularly glycoprotein Ib. VWF will also bind to components of the endothelial matrix, such as collagen. Once it is bound to the receptors, factor VIII, and to matrix components, the factor will then create an adhesive bridge to the location of injury by the use of collagen and platelets. Factor VIII is important in activating the process of coagulation. After factor VIII becomes activated, it is cleaved by thrombin. | |
== Structure == | == Structure == | ||
- | + | The von Willebrand factor contains four domains from A-D. The A and B domains contain 3 different domains and C has two domains, while D has four. Each domain plays a role in different functions. For example, domains D’ and D3 exhibit binding sites for factor VIII. The structure of VWF was changed from the original thought structure in 1986. The original structure showed to be: D1-D2-D’-D3-A1-A2-A3-D4-B1-B2-B3-C1-C2-CK. However, the new shows the structure is D1-D2-D’-D3-A1-A2-A3-D4-C1-C2-C3-C4-C5-C6-CK. The A1 domain of VWF is the binding site Ib alpha glycoprotein and for collagen. The A2 domain is responsible for binding the cleavage site to ADAMTS-13. ADAMTS-13 is a metalloprotease that cleaves the VWF between the tyrosine and methionine located on positions 842 and 843, respectively. The size of VWF is crucial as the bigger the factor, the more able the factor can anchor platelets. | |
== Disease == | == Disease == | ||
Revision as of 19:05, 30 April 2018
This Sandbox is Reserved from Jan 22 through May 22, 2018 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, Missouri, USA. This reservation includes Sandbox Reserved 1446 through Sandbox Reserved 1455. |
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von Willebrand Factor
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References
1. Desch, K. C. (2018). Regulation of plasma von Willebrand factor. F1000Research, 7, 96. http://doi.org/10.12688/f1000research.13056.1