Sandbox Reserved 1448

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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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Lactate dehydrogenase is a quaternary structure found in humans. It has two main subunits, H and M (heart and muscle). The H form converts pyruvates to lactate, while the M form converts lactate to pyruvates. Based on the different reactions the two subunits preform, different combinations can be found throughout the body. 4H is found in the heart, 3H1M is found in the reticuloendothelial (part of the immune system), 2H2M is found in the kidneys, and 4M is found in the muscles and liver. Lactate dehydrogenase is a main component of anaerobic respiration within the human body. This molecule come into play when there is a lack of oxygen, such as during intense exercise. During intense exercise our body requires a larger amount of oxygen, and glycolysis becomes our main source of energy. In order for glycolysis to work smoothly and avoid access NADH, we need available oxygen. This is where LDH (lactase dehydrogenase) comes into play. LDH converts pyruvate into lactate, giving our body more ATP. When we halt the exercise and take a deep breath LDH converts the lactate back to pyruvate, and we continue on our normal aerobic pathway of glycolysis.
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Overview here
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== Function ==
== Function ==
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LDH is a key enzyme for aerobic respiration. This molecule comes into play when there is a lack of oxygen, such as during intense exercise. During intense exercise our body requires a larger amount of oxygen, and glycolysis becomes our main source of energy. In order for glycolysis to work smoothly and avoid access NADH, we need available oxygen. This is where LDH (lactase dehydrogenase) comes into play. LDH converts pyruvate into lactate, giving our body more ATP. When we halt the exercise and take a deep breath LDH converts the lactate back to pyruvate, and we continue on our normal aerobic pathway of glycolysis.
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== Disease ==
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== Relevance ==
== Relevance ==
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LDH allows humans to perform strenuous exercises for a longer length of time.
== Structural highlights ==
== Structural highlights ==
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https://www.rcsb.org/structure/4nd4
https://www.rcsb.org/structure/4nd4
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http://proteopedia.org/wiki/index.php/Help:Editing#Citing_Literature_References

Revision as of 19:16, 30 April 2018

This Sandbox is Reserved from Jan 22 through May 22, 2018 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, Missouri, USA. This reservation includes Sandbox Reserved 1446 through Sandbox Reserved 1455.
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Human Lactate Dehydrogenase

Caption for this structure

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References


https://www.rcsb.org/structure/4nd4 http://proteopedia.org/wiki/index.php/Help:Editing#Citing_Literature_References

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