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User:Christian Fjeld/Sandbox 1

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== General Description ==
== General Description ==
<StructureSection load='4aq7' frame='true' size='340' side='right' scene='78/786656/Lars/1' caption='LARS (''E coli'') ternary complex with tRNA''leu'' and leucyl adenylate analogue' scene=''>
<StructureSection load='4aq7' frame='true' size='340' side='right' scene='78/786656/Lars/1' caption='LARS (''E coli'') ternary complex with tRNA''leu'' and leucyl adenylate analogue' scene=''>
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Leucyl tRNA synthetase (LARS) is a 97 kDa, class IA aminoacyl-tRNA synthetase (ARS) that catalyzes the ligation of leucine with tRNA<sup>leu</sup> in an ATP dependent mechanism. LARS is a cytoplasmic enzyme that is found as part of the multisynthetase complex in mammals<ref>doi: 10.1007/978-3-319-46503-6_18</ref>.
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Leucyl tRNA synthetase (LARS) is a 97 kDa, class IA aminoacyl-tRNA synthetase (ARS) that catalyzes the ligation of leucine with tRNA<sup>leu</sup> in an ATP dependent mechanism. LARS is a cytoplasmic enzyme that is found as part of the multisynthetase complex in mammals<ref>doi: 10.1007/978-3-319-46503-6_18</ref>. LARS has been shown to be involved with the mTOR pathways as a sensor of leucine levels within the cell<ref>doi: 10.1016/j.cell.2012.02.044</ref>.
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Mutations in LARS2, the mitochondrial version of the enzyme, have been linked to Perrault syndrome characterized by premature ovarian failure in females and progressive hearing loss in both sexes<ref>doi: 10.1016/j.ajhg.2013.03.007</ref>
== Structure ==
== Structure ==

Revision as of 21:44, 30 April 2018

General Description

PDB ID 4aq7

Drag the structure with the mouse to rotate

3D Structure of LARS

Updated on 30-April-2018

References

  1. ↑ Mirande M. The Aminoacyl-tRNA Synthetase Complex. Subcell Biochem. 2017;83:505-522. doi: 10.1007/978-3-319-46503-6_18. PMID:28271488 doi:http://dx.doi.org/10.1007/978-3-319-46503-6_18
  2. ↑ Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell. 2012 Apr 13;149(2):410-24. doi: 10.1016/j.cell.2012.02.044. Epub 2012 Mar, 15. PMID:22424946 doi:http://dx.doi.org/10.1016/j.cell.2012.02.044
  3. ↑ Pierce SB, Gersak K, Michaelson-Cohen R, Walsh T, Lee MK, Malach D, Klevit RE, King MC, Levy-Lahad E. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome. Am J Hum Genet. 2013 Apr 4;92(4):614-20. doi: 10.1016/j.ajhg.2013.03.007. Epub, 2013 Mar 28. PMID:23541342 doi:http://dx.doi.org/10.1016/j.ajhg.2013.03.007

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Christian Fjeld

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