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2hl8

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|PDB= 2hl8 |SIZE=350|CAPTION= <scene name='initialview01'>2hl8</scene>, resolution 2.000&Aring;
|PDB= 2hl8 |SIZE=350|CAPTION= <scene name='initialview01'>2hl8</scene>, resolution 2.000&Aring;
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|LIGAND= <scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene>
|ACTIVITY=
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|DOMAIN=
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|RELATEDENTRY=[[2hkp|2HKP]], [[2hl9|2HL9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hl8 OCA], [http://www.ebi.ac.uk/pdbsum/2hl8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hl8 RCSB]</span>
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:18:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:53 2008''

Revision as of 00:31, 31 March 2008

Image:2hl8.gif


PDB ID 2hl8

Drag the structure with the mouse to rotate
, resolution 2.000Å
Ligands:
Related: 2HKP, 2HL9


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfinic acid


Overview

Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast. The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular substrate Smt3, the yeast SUMO homolog. The Ulp1-Smt3 crystal structure and functional testing of elements within the conserved interface elucidate determinants of SUMO recognition, processing, and deconjugation. Genetic analysis guided by the structure further reveals a regulatory element N-terminal to the proteolytic domain that is required for cell growth in yeast.

About this Structure

2HL8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast., Mossessova E, Lima CD, Mol Cell. 2000 May;5(5):865-76. PMID:10882122

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