2hms

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|PDB= 2hms |SIZE=350|CAPTION= <scene name='initialview01'>2hms</scene>, resolution 2.700&Aring;
|PDB= 2hms |SIZE=350|CAPTION= <scene name='initialview01'>2hms</scene>, resolution 2.700&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE'>NAI</scene>
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|LIGAND= <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= yuaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
|GENE= yuaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
 +
|DOMAIN=
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|RELATEDENTRY=[[1lsu|1LSU]], [[1lss|1LSS]], [[1lnq|1LNQ]], [[2hmt|2HMT]], [[2hmu|2HMU]], [[2hmv|2HMV]], [[2hmw|2HMW]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hms OCA], [http://www.ebi.ac.uk/pdbsum/2hms PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hms RCSB]</span>
}}
}}
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[[Category: Albright, R A.]]
[[Category: Albright, R A.]]
[[Category: Morais-Cabral, J H.]]
[[Category: Morais-Cabral, J H.]]
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[[Category: NAI]]
 
[[Category: ion transporter]]
[[Category: ion transporter]]
[[Category: ktn]]
[[Category: ktn]]
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[[Category: symporter]]
[[Category: symporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:18:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:27 2008''

Revision as of 00:32, 31 March 2008

Image:2hms.gif


PDB ID 2hms

Drag the structure with the mouse to rotate
, resolution 2.700Å
Ligands:
Gene: yuaA (Bacillus subtilis)
Related: 1LSU, 1LSS, 1LNQ, 2HMT, 2HMU, 2HMV, 2HMW


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Rectangular-shaped octameric ring structure of an RCK domain with NADH bound


Overview

The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.

About this Structure

2HMS is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:16990138

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