5kw2
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation== |
| - | + | <StructureSection load='5kw2' size='340' side='right' caption='[[5kw2]], [[Resolution|resolution]] 2.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kw2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KW2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6XQ:(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic+acid'>6XQ</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kw2 OCA], [http://pdbe.org/5kw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/5kw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kw2 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[http://www.uniprot.org/uniprot/FFAR1_HUMAN FFAR1_HUMAN]] Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.<ref>PMID:12496284</ref> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | + | </StructureSection> | |
| + | [[Category: Lysozyme]] | ||
| + | [[Category: Baker, K A]] | ||
[[Category: Benach, J]] | [[Category: Benach, J]] | ||
| - | [[Category: | + | [[Category: Chau, B]] |
| + | [[Category: Chen, Y]] | ||
[[Category: Conners, K]] | [[Category: Conners, K]] | ||
| - | [[Category: | + | [[Category: Genin, M J]] |
| - | [[Category: | + | [[Category: Gheyi, T]] |
| - | [[Category: | + | [[Category: Groshong, C]] |
| - | [[Category: | + | [[Category: Hamdouchi, C]] |
| - | [[Category: | + | [[Category: Ho, J D]] |
| + | [[Category: Kahl, S D]] | ||
| + | [[Category: Lee, M R]] | ||
| + | [[Category: Lewis, A P]] | ||
| + | [[Category: Linswala, J P]] | ||
[[Category: Lu, F]] | [[Category: Lu, F]] | ||
| - | [[Category: | + | [[Category: Madsen, R E]] |
| - | [[Category: | + | [[Category: Miller, A R]] |
[[Category: Montrose-Rafizadeh, C]] | [[Category: Montrose-Rafizadeh, C]] | ||
| - | [[Category: | + | [[Category: Otto, K A]] |
| - | [[Category: | + | [[Category: Reynolds, N A]] |
| + | [[Category: Riley, J P]] | ||
| + | [[Category: Rodgers, L]] | ||
| + | [[Category: Saflor, M D]] | ||
[[Category: Song, M]] | [[Category: Song, M]] | ||
| - | [[Category: | + | [[Category: Wilbur, K L]] |
| - | [[Category: | + | [[Category: Yang, H C]] |
| - | [[Category: | + | [[Category: Fatty acid binding protein-hydrolase complex]] |
| + | [[Category: Free fatty acid receptor 1]] | ||
| + | [[Category: G-protein coupled receptor]] | ||
| + | [[Category: Lipid-binding protein]] | ||
Revision as of 07:55, 2 May 2018
The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
| |||||||||||
Categories: Lysozyme | Baker, K A | Benach, J | Chau, B | Chen, Y | Conners, K | Genin, M J | Gheyi, T | Groshong, C | Hamdouchi, C | Ho, J D | Kahl, S D | Lee, M R | Lewis, A P | Linswala, J P | Lu, F | Madsen, R E | Miller, A R | Montrose-Rafizadeh, C | Otto, K A | Reynolds, N A | Riley, J P | Rodgers, L | Saflor, M D | Song, M | Wilbur, K L | Yang, H C | Fatty acid binding protein-hydrolase complex | Free fatty acid receptor 1 | G-protein coupled receptor | Lipid-binding protein
