5ng4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human CEP135 parallel dimeric coiled coil 82-144== | |
| - | + | <StructureSection load='5ng4' size='340' side='right' caption='[[5ng4]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ng4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NG4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ng4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ng4 OCA], [http://pdbe.org/5ng4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ng4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ng4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ng4 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CP135_HUMAN CP135_HUMAN]] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP135_HUMAN CP135_HUMAN]] Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.<ref>PMID:17681131</ref> <ref>PMID:18851962</ref> <ref>PMID:26675238</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bianchi, S]] | ||
| + | [[Category: Kraatz, S H.W]] | ||
| + | [[Category: Steinmetz, M O]] | ||
| + | [[Category: Centrosome]] | ||
| + | [[Category: Cep135]] | ||
| + | [[Category: Coiled coil]] | ||
| + | [[Category: Disulfide bridge]] | ||
| + | [[Category: Microtubule-binding protein]] | ||
Revision as of 07:56, 2 May 2018
Human CEP135 parallel dimeric coiled coil 82-144
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