5xi2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==BRD4 bound with compound Bdi2== | |
| - | + | <StructureSection load='5xi2' size='340' side='right' caption='[[5xi2]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xi2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XI2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8F9:(3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one'>8F9</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi2 OCA], [http://pdbe.org/5xi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi2 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cao, D]] | [[Category: Cao, D]] | ||
| + | [[Category: Li, Y]] | ||
[[Category: Xiong, B]] | [[Category: Xiong, B]] | ||
| - | [[Category: | + | [[Category: Chromatin regulator]] |
| + | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 08:03, 2 May 2018
BRD4 bound with compound Bdi2
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