5xwz

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m (Protected "5xwz" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xwz is ON HOLD until Jun 30 2019
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==Crystal structure of a lactonase from Cladophialophora bantiana==
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<StructureSection load='5xwz' size='340' side='right' caption='[[5xwz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xwz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XWZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwz OCA], [http://pdbe.org/5xwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xwz RCSB], [http://www.ebi.ac.uk/pdbsum/5xwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwz ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zearalenone (ZEN) is a mycotoxin which causes huge economic losses in the food and animal feed industries. The lactonase ZHD101 from Clonostachys rosea, which catalyzes the hydrolytic degradation of ZEN, is the only known ZEN-detoxifying enzyme. Here, a protein homologous to ZHD101, denoted CbZHD, from Cladophialophora batiana was expressed and characterized. Sequence alignment indicates that CbZHD possesses the same catalytic triad and ZEN-interacting residues as found in ZHD101. CbZHD exhibits optimal enzyme activity at 35 degrees C and pH 8, and is sensitive to heat treatment. The crystal structure of apo CbZHD was determined to 1.75 A resolution. The active-site compositions of CbZHD and ZHD101 were analyzed.
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Authors: Zheng, Y.Y., Liu, W.T., Liu, W.D., Chen, C.C., Guo, R.T.
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Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana.,Hui R, Hu X, Liu W, Liu W, Zheng Y, Chen Y, Guo RT, Jin J, Chen CC Acta Crystallogr F Struct Biol Commun. 2017 Sep 1;73(Pt 9):515-519. doi:, 10.1107/S2053230X17011840. Epub 2017 Aug 21. PMID:28876230<ref>PMID:28876230</ref>
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Description: Crystal structure of a lactonase from Cladophialophora bantiana
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Liu, W.T]]
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<div class="pdbe-citations 5xwz" style="background-color:#fffaf0;"></div>
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[[Category: Chen, C.C]]
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== References ==
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[[Category: Liu, W.D]]
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<references/>
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[[Category: Guo, R.T]]
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__TOC__
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[[Category: Zheng, Y.Y]]
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</StructureSection>
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[[Category: Chen, C C]]
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[[Category: Guo, R T]]
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[[Category: Liu, W D]]
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[[Category: Liu, W T]]
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[[Category: Zheng, Y Y]]
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[[Category: Alpha/beta-hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Lactonase]]
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[[Category: Zearalenone]]

Revision as of 08:04, 2 May 2018

Crystal structure of a lactonase from Cladophialophora bantiana

5xwz, resolution 1.75Å

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