5yj8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Identification of a small molecule inhibitor for the Tudor domain of TDRD3== | |
| - | + | <StructureSection load='5yj8' size='340' side='right' caption='[[5yj8]], [[Resolution|resolution]] 1.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yj8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YJ8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8W9:5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one'>8W9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yj8 OCA], [http://pdbe.org/5yj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5yj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yj8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN]] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Liu, J]] | [[Category: Liu, J]] | ||
[[Category: Ruan, K]] | [[Category: Ruan, K]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
| + | [[Category: Transcriptional coactivator]] | ||
Revision as of 08:05, 2 May 2018
Identification of a small molecule inhibitor for the Tudor domain of TDRD3
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